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10.1016/j.freeradbiomed.2016.12.030 108 KreutzmannM.KrausB

NAD plays a key role in cellular energy production and is needed by more than 400 enzymes to catalyze reactions in the body

reports grants and consultancy or industry support from Electrocore, Medtronic, Eli Lilly, Amgen, Novartis, Satsuma, Lundbeck, and TEVA, and independent support from The Netherlands Organisation for Scientific Research (NWO), The Netherlands Organisation for Health Research and Development (ZonMW), The Dutch Brain Foundation, The Dutch Heart Foundation, The Dutch Ministry of Health, and The NutsOhra Foundation from the Dutch Insurance Companies

It showed significant enhancements in wrinkle reduction (crows feet), skin firmness, tone, and texture, confirmed via expert grading and photographic instrumentation (see study here)